有去无回 is a fixed phrase (成语) that literally means 'having gone, no return'. It describes a situation where someone or something departs and never comes back — often used to stress a decision or action that is a point of no return, like crossing the Rubicon. You can use it for trips, investments, life choices, or anything irreversible. Do not use it for mere one-way travel; it carries a sense of finality and consequence.